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AGE RELATED MACULAR DEGENERATION

Why is the macula important?

macular degeneration treatmentUnlike a photograph in which the entire picture is in focus, our eyes can only focus on the object at which we are looking directly. (Try reading the first word of this sentence while staring at the period at the end of the sentence).
Thinking of the eye as a camera, the retina is the film in the back. The macula is the center of this film. The macula is responsible for our clear central vision. The remainder of the retina is used for side or peripheral vision. Damage to the macula causes blurring of our central vision, which may make it difficult to read, drive, watch television, and recognize familiar faces.

What is macular degeneration?

Macular degeneration is the leading cause of poor vision in the United States. Each year, approximately 170,000 new cases of age-related macular degeneration (AMD) are discovered. Macular degeneration occurs whenever a previously normal macula begins to deteriorate. AMD accounts for 90 percent of new legal blindness in the US. The visual symptoms of AMD involve loss of central vision. While peripheral vision is unaffected, one loses the sharp, straight-ahead vision necessary for driving, reading, recognizing faces, and generally looking at detail. Imagine being able to see a clock on the wall but unable to make out the time or unable to read because you could not see parts of words on the page. As AMD progresses, the central vision begins to blur, but the peripheral vision remains normal. Please remember that macular degeneration does not cause total blindness. Even at its worst, AMD spares peripheral vision and allows patients to care for themselves. Macular degeneration often affects both eyes, although the second eye may not become involved for many years. There are two main types of AMD: dry macular degeneration and wet macular degeneration . Ninety percent of macular degeneration patients have the dry form. The cells in the macula slowly wear out. The loss of central vision is often mild. Some patients may have progressive deterioration, usually over a long period of time, resulting in severe loss of central vision. Only 10 percent of severe loss of central vision is due to dry AMD. The more severe wet (exudative form) affects 10 percent of macular degeneration patients. In this type, fluid may collect or abnormal blood vessels may grow underneath the retina. They often cause severe damage to the vision from bleeding and scarring under the macula. The wet form accounts for 90 percent of the patients with severe loss of central vision.

What causes age related macular degeneration?

While age is the most significant risk factor for developing AMD; heredity, blue eyes, high blood pressure, cardiovascular disease, and smoking have also been identified as risk factors. Heredity plays a role in many patients. The disorder is limited to the eye and is not associated with problems elsewhere in the body. Tumors and infections are not associated with macular degeneration. Extensive use of the eyes and reading or watching television does not cause macular degeneration or result in further damage. There is nothing a person can do that will accelerate or retard the progress of AMD, although, there are some suggestions that ultraviolet blocking sunglasses and antioxidant vitamins may have a protective effect.

How do I know if I have age related mcular degeneration?

Most people with macular degeneration have either blurred or distorted vision in one or both eyes. Distorted or wavy vision is a very important symptom and should be reported promptly to your doctor. This is especially true when straight lines (doorways, telephone poles, etc.) appear wavy. Many people with visual loss in one eye may not realize they have a problem because the good eye takes over for both eyes.
You will be given a special Amsler grid test to be used at home to help you recognize early changes in your vision or identify new areas of distortion. This grid test should be used on a daily basis. It is very important to check each eye separately. There is a sample grid included with this material with instructions for its use.

What test can I expect if I have AMD?

The doctor will examine your eyes on each visit. If necessary, he may order a fluorescein angiogram . In this test, a dye is injected into an arm vein, and pictures are taken of the macula as the dye circulates through the blood vessels. In some cases, another type of angiogram, called High Speed-ICG, is used to take a movie of the deepest layers of the eye using a different dye and a special infrared camera. Because the vessels of the eye can be photographed directly, no X-rays are involved and the tests are safe for patients who are allergic to X-ray dyes. Patients allergic to Iodine should only have High Speed-ICG with special precautions. The angiogram provides a detailed picture of the retinal blood vessels and will detect any abnormal vessels that might be present. The doctor uses this information to determine whether treatment might be helpful. The dye is excreted in your urine for up to 24 hours following the injection. The whites of your eyes and your skin might turn slightly yellow for a day. Hospitalization is not required for this test, and you are free to go home when it is finished.

What treat ments is available for AMD?

There are no medicines, eye drops, or surgery that have been shown to be effective in curing macular degeneration. The only proven treatment is laser photocoagulation. Conventional laser treatment only benefits a small percentage of macular degeneration patients who have certain types of the wet form. However, laser can stabilize vision and prevent further deterioration and in some cases, improve vision to some degree.

Conventional Laser Treatment

Conventional laser consists of a strong beam of light, which enables the physician to seal (cauterize) the abnormal blood vessels, which may grow in the wet form of macular degeneration. Before the laser procedure, an anesthetic injection may be used. The injection often causes the vision in the treated eye to be blurred for several hours. You will be in a sitting position for the treatment. An eye patch may be placed over the eye for several hours following the treatment. The actual laser treatment, which is not painful, usually takes less than 5 minutes. You will be able to return home immediately and resume your normal activities within 24 hours. Unfortunately, only some types of wet AMD respond to conventional laser. Laser treatment does not cure macular degeneration, and it does not necessarily prevent abnormal blood vessels from returning in the future. It is important for you to continue to test your vision with the Amsler grid chart. If further changes are noted, they should be reported promptly to your doctor. If the abnormal blood vessels do return, it may be possible to treat them with laser again.

Newer Laser Techniques

Abnormal new blood vessels may grow into the very center of the macula in some cases of macular degeneration. These vessels may grow in a variety of patterns. Depending on the pattern of leakage, one of the new laser treatment techniques may be appropriate for an individual case. If the vessels are very well defined, photodynamic therapy may be the best treatment recommendation. This involves injection of a medicine called Visudyne, which is selectively absorbed by abnormal, growing blood vessels. The medicine is allowed to adsorb for 15 minutes after beginning infusion through an intravenous line. Nonburning, red laser light is then shown into the eye, which activates the medicine. This chemically cauterizes the abnormal blood vessels, with relatively little effect on the surrounding normal tissue. This results in visual improvement in only about 15 to 20 percent of cases, but prevents further vision loss in another 50 to 60 percent. This is not the cure, but an effective way to prevent further vision loss in many patients. If vessels grow in the center of the macula, resulting in a diffuse pattern of fluid leakage, photodynamic therapy has been shown not to be helpful. In these cases, transpupillary thermal therapy, another new treatment technique may be useful. Instead of applying a hot laser, which burns the tissue that it touches, transpupillary thermal therapy involves gently heating this area with much cooler laser settings. This results in very mild photocoagulation of the abnormal tissue, with less damage to surrounding normal tissue. This has been shown to stabilize or improve vision in 50 to 70 percent of patients with this pattern of leakage. All of these treatments seek to treat the area of leakage directly. These leaky blood vessels grow in a pattern like a small flat tree or bush underneath the retina. In many cases, it would be just as effective to treat the underlying trunk blood vessel, which feeds this tree. In the past, available cameras have not been able to visualize the feeder vessel. There is a new kind of camera becoming available which can, in many cases, visualize this feeder vessel. Feeder vessel therapy has been shown to be useful in some cases not treatable by other means.

Medications

No medications have been proven to be effective for macular degeneration. However, some research suggests that certain dietary supplements may help. Vitamins and minerals such as zinc, vitamin E and selenium are advocated by some researchers for the purpose of trying to prevent further visual loss from dry macular degeneration. Other substances that have received much attention include Bilberry and Lutein. Current studies may determine whether these medications are really helpful. Your doctor will discuss them with you if he or she feels they might be appropriate for you.

Dietary Measures

In addition to the vitamins listed above, some people do believe that certain foods, which contain these vitamins, or other factors may help control the progression of macular degeneration. Such foods include dark green leafy vegetables, red wine (particularly the Cabernet and Petit Sirah grapes) and other foods rich in antioxidant vitamins.

Surgery

Very few patients with AMD will need surgery. Surgery may be considered when abnormal new vessels grow in the center of the macula or when a very large hemorrhage occurs. These are instances in which the eye is threatened with severe visual loss. Your doctor will discuss this further if it is appropriate.

New Research

There are many new research studies under way to look for other treatments for specific types of macular degeneration. These include studies looking at drugs, such as thalidomide, to inhibit the growth of blood vessels. Another study is looking at a substance, called rhuFab V2, which affects the immune system in a manner that may inhibit vessel growth.
There is also a study looking at using an infrared laser to treat early, dry macular degeneration so as to prevent further deterioration. Other studies are looking at surgical techniques to manage the disease and even implanting electronic chips to generate images. The doctors at can keep you up-to-date on new research efforts.

Low vision Aids

For those patients with AMD who lose central vision, low vision aids may help to maintain the ability to do everyday tasks. These aids range from spectacle and hand-held magnifying glasses to special lighting devices. Telescopic clip-on lenses to fit over your present glasses are sometimes used to improve distance vision. Special television systems may help restore slow reading ability to those patients who have severe loss of central vision. Low vision aids are prescribed by specialists who will be recommended by The Eye Centers of Racine & Kenosha doctor if appropriate.

Here at The Eye Centers of Racine & Kenosha we keep up to date on new research and new treatments. Call 262 637 0500 today!  to scheduled your appointment.

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In addition, the New York Times prints a weekly newspaper in large print for those with limited vision. (The New York Times Large Type Weekly, P.O. Box 2570, Boulder, Colorado 80303); Reader’s Digest also publishes in large print. (Reader’s Digest Association, Pleasantville, New York 10571); Large print books are published by G.K. Hall, (70 Lincoln Street, Boston, Massachusetts, 1-800-343-2806) and are available at most bookstores.

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